The clinical and ethnic decision of surgery for congenital heart disease (CHD) for trisomy 13 (T13) or trisomy 18 (T18) remains controversial. However, recent data showed that corrective cardiac surgery for simple CHD or palliative cardiac surgery for complex lesion may have short-term survival benefit, although long-term survivla benefit or improvement for delayed development is uncertain. We retrospectively reviewed clinical data of T13 or T18 patients diagnosed during recent 10 years. Variants of T13 or T18 were excluded due to distinct nature, and total of 14 patients (8 with T13 and 6 with T18) were reviewed. Mean follow-up duration was 5 months (range, 0.1 to 22.3). Half of patients were died within 3 months, and 2 (14.2%) patients survived for 1 years, and 4 patients (28.4%) were still alive. For cardiac problem, double oulet right ventricle (n=5, tetralogy of fallot type, n=3 or with endocardial cushion defect, n=2) were most common followed by ventricular setpal defect (n=4), atrial septa defect (n=2), pulmonary atresia with intact ventricular septum (n=1), coarctation of aorta (n=1) and hypoplastic left heart syndrome (n=1). Neurologic problem was occured in most patients (13/14, 92.8%), and most common problem was agenesis of corpus callosum. Cardiac surgery was perfomed in 5 patients (corrective surgery and one palliative). Cardiac surgery group have longer survival (9.8 vs 2.2 months, p = 0.022), although there was one mortality related with postoperative arrhythmia. Except early mortality, 4 patients survived for 8.9 month (range 5.0 to 14.5). Individual clinical and ethnic assesment for CHD surgery is mandatory for these patients.